Visible-Light-Induced Cross-Dehydrogenative Coupling of Heteroarenes with Aliphatic Alcohols Mediated by Iodobenzene Dichloride

Abstract

With the irradiation of visible light, α-heteroarylation of aliphatic alcohol was selectively achieved under gentle conditions in the present of iodobenzene dichloride. The Minisci-type cross-dehydrogenative coupling reaction was performed in the absence of metal and acid. Readily available primary alcohols and electron-withdrawing heteroarenes can be applied smoothly. Mechanism studies indicated that the PhICl radical and chlorine radical formed from iodobenzene dichloride were responsible for the selective hydrogen atom abstraction of alcohols.