Synthesis and characterization of quantum dot chains: Self-assembly of mercaptopropionic-acid-capped quantum dots conjugated with short single-stranded DNA

Abstract

In this paper, we describe the synthesis and characterization of quantum dot (QD) chains. We used small QD-DNA conjugates, i.e., short-ligand-capped QDs conjugated with short (15-mers) single-stranded DNA, as the building blocks. The small conjugates were separated based on the valence of the DNA, i.e., the amount of DNA per particle, using agarose gel electrophoresis. The conjugates formed self-assemblies composed of closely spaced (inter-particle spacing of 0.6-2 nm) QDs. We report the results of our investigation of the electrophoresis and hybridization of the conjugation.