Critically ill patients exhibit reduced melatonin secretion, both in nocturnal peaks and basal daytime levels. Oral melatonin supplementation may be useful for known sedative and antioxidant properties.
CITATION STYLE
Moroni, B., Mistraletti, G., Reiter, R., Esposti, R., D’Angelo, E., Formenti, P., … Iapichino, G. (2010). Pharmacokinetics of orally administered melatonin in critically ill patients. Critical Care, 14(Suppl 1), P494. https://doi.org/10.1186/cc8726
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