A confocal microscopy study of the anterior corneal mosaic in the sub-basal nerve plexus

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Abstract

In vivo confocal microscopy of the corneal sub-basal nerve plexus and assessment of its morphology promises to provide a novel, highly sensitive tool for early diagnosis and therapy monitoring of diabetic peripheral neuropathy. Ridge-like tissue deformations in the region of the sub-basal nerve plexus, induced by pressure upon the corneal surface, can prevent the imaging of sub-basal nerves over the entire field of view and impede the assessment of nerve morphology. We present an investigation of the distribution of the deformation heights, yielding a mean value of 28.9 μm in our data. Given the depth of focus of the used confocal microscope of 6-7 μm, our results strongly suggest the need for three-dimensional imaging methods for the reliable assessment of sub-basal nerve morphology. © 2013 by Walter de Gruyter.

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Allgeier, S., Eberle, F., Köhler, B., Maier, S., Van Wezel, J., Zhivov, A., & Bretthauer, G. (2013). A confocal microscopy study of the anterior corneal mosaic in the sub-basal nerve plexus. Biomedizinische Technik, 58(SUPPL.1). https://doi.org/10.1515/bmt-2013-4270

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