Synthesis and in vitro antimicrobial evaluation of a new metronidazole derivative

Abstract

INTRODUCTION: For decades there has been active work on the synthesis, identification, and exploration of heterocyclic compounds. However, the imidazole nucleus is the main scaffold in molecules with various pharmacological properties such as antibacterial, antifungal, antineoplastic, antiviral, antidiabetic, etc. This work describes a synthesis of new metronidazole amide derivative by condensation of-(2-methyl-5-nitro-1Н-imidazole-1-yl)acetic acid with 2-(diethylamino)ethyl 4-aminobenzoate (procaine). The chemical structure of the new compound was confirmed by its IR and UV-VIS spectral data and was evaluated for in vitro potential antimicrobial activity against standard bacterial strains of Staphylococcus aureus ATCC 29213, Escherichia coli ATCC 25922, and Candida albicans ATCC 10231.