Efficient oxidative chlorination of aromatics on saturated sodium chloride solution

Abstract

An efficient metal-free system using saturated aqueous sodium chloride/aqueous ammonium chloride solution as chlorine source and potassium persulfate as a cheap oxidant for the chlorination of various aromatic compounds including deactivated ones has been developed that proceeds without any acid additive in an excellent regioselective manner. The easy-to-handle aqueous solution/acetonitrile biphasic system as solvent and no need for precautionary measures make this process very practical. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.