Constituents of medicinal plants of Lombok: A new antibacterial alkaloid from Voacanga foetida (Bl.) Rolfe

Abstract

A new, weakly antibacterial indole alkaloid, named lombine, together with the known alkaloid voacangine, have been isolated from the bark of Voacanga foetida (Bl.) Rolfe (Apocynaceae), a plant used on Lombok Indonesia, for medicinal purposes. A combined chemo- and bio-rational strategy was developed to target this plant for investigation. Lombine was shown to be bactericidal against Staphylococcus aureus and Escherichia coli.