Periodontal effect of 8% Hyaluronan as an Adjunct to Scaling and Root Planning in the Treatment of Chronic Periodontitis(Comparative Study)

Abstract

Background:Hyaluronic acid showed the anti-inflammatory, anti-edematous, anti-oxidant, and bacteriostatic effect on periodontal disease; the potential benefits of the periodontal effect of a single dose of hyaluronic acid on the clinical parameters were evaluated in this study. Methods: Thirty patients with chronic periodontitis were recruited to participate in this study. They were divided into three groups; the first group (10 patients) was treated with SRP and 8% hyaluronic acid gel was additionally applied, the second group (10 patients) was treated with SRP, and the third group (10 patients) was treated with 8% hyaluronic acid gel only. The clinical parameters which include Plaque index (PLI),Gingival index (GI), Bleeding on probing(BOP) and Relative Attachment level wereassessed at base line , one week and four weeks post treatment. Hyaluronic gel was administered subgingivally in the test sites at baseline Results:The main results of the three treated groups was summarized as follows: 1. A significant reduction in bleeding on probing and RAL was observed in all groups after four weeks (P <0.05), 2. Significantly lower bleeding on probing were observed in the hyaluronan groups, group 1and 3 compared to group 2 after 4 weeks (P <0.05), 3. RAL reductions between the groups were statistically significant. Conclusion:The local applications of hyaluronan gel (0.8%) in conjunction with scaling and root planning or used it only have a beneficial effect on clinical periodontal parameter in patients with chronic periodontitis.