DETERMINATION OF ESCITALOPRAM OXALATE IN PHARMACEUTICAL FORMULATION BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY

  • Charde M
  • Bhavsar N
  • Chakole R
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Abstract

A simple, precise and sensitive reverse-phase high performance liquid chromatographic (RP-HPLC) method has been developed for the quantitation of Escitalopram oxalate in pharmaceutical formulations.  Chromatographic separation was achieved on a 250 × 4.6 mm, 5μ, C18 column.  The flow rate was 1ml/min and eluent was monitored by absorbance at 240 nm using a mixture of Acetonitrile and Buffer (pH 4.0) in the ratio of 25:75 (v/v).  The retention times of Escitalopram oxalate was found to be 3.2 min.  Calibration plots were linear in the concentration range of 2.5-80 μg mL-1 for Escitalopram oxalate.  The total run time is 10 min.  The proposed method was validated by testing its linearity, recovery, specificity, system suitability, precision (Interday and intraday), robustness and LOD/LOQ values and it was successfully employed for the determination of Escitalopram oxalate in pharmaceutical tablet formulations.

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Charde, M. S., Bhavsar, N., & Chakole, R. D. (2012). DETERMINATION OF ESCITALOPRAM OXALATE IN PHARMACEUTICAL FORMULATION BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY. International Journal of Pharmaceutical Chemistry, 2(1). https://doi.org/10.7439/ijpc.v2i1.422

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