Probing extracellular acidity of live cells in real time for cancer detection and monitoring anti-cancer drug activity

Abstract

We report a novel electrochemical strategy to probe the microenvironment of live cells in real time in terms of its extracellular pH. This approach allowed highly sensitive detection of cancer cells down to five cells. Utility of the sensor for evaluating the efficacy of glycolysis inhibiting anti-cancer drugs is also demonstrated. This journal is