Antibacterial study of gellan gum (GG) film incorporated norfloxacin

Abstract

A series of norfloxacin-loaded films were fabricated by combining with gellan gum (GG) using evaporative casting technique. The films were evaluated in terms of morphological, water vapour transmission rates (WVTR), water uptake, release study and antibacterial study. The prepared films contained smooth appearance of cross-section distributed by good film of materials. The results indicated that the film swelling were increased at higher concentration of norfloxacin loaded, however decreased the WVTR properties. All films showed almost 100 % of drug release within 5 - 20 minutes. It was found that, the antibacterial activity was directly proportional to the release rate which is at higher concentration of norfloxacin resulted in stronger antibacterial properties.