El comportamiento del factor de necrosis tumoral alfa e interleucina 6 en lesiones de vías biliares postcolecistectomía

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Abstract

Background: During cholecystectomy, the bile duct may be injured. When this complication occurs, Kupffer cells are activated and produce tumor necrosis factor alpha (TNF-a) and interleukin-6 (IL6) to phagocyte toxic products Aim: To measure serum levels of TNF-a and IL-6 among patients that suffered a bile duct injury after a cholecystectomy. Patients and Methods: Serum levels of TNF-a and IL-6 were measured prior to the bile-enteric derivation and after one year of follow-up, in 31 patients that had a complete bile duct obstruction after open or laparoscopic cholecystectomy and in 5 healthy controls. Results: At baseline TNF-a levels in healthy subjects and patients with bile duct injury were 0 and 43.9 ± 2.9 ng/mL, respectively (p < 0.01). At one year of follow up, TNF-a became undetectable among patients. At baseline, the values for IL-6 among healthy controls and patients were 3.0 ± 2.0 and 72.0 ± 94.7 pg/mL respectively, (p < 0,004). After one year of follow up, IL-6 levels decreased to 6.4 ± 0.3 pg/mL among patients. Conclusions: TNF-a and IL-6 levels were elevated before bile-enteric derivation among patients with bile duct injury and became normal one year later.

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Miranda-Díaz, A. G., Hermosillo-Sandoval, J. M., Huerta-Rosas, G., López-Guillén, G. G., Cardona-Muñoz, E. G., García-Iglesias, T., … Alatorre-Carranza, M. D. P. (2010). El comportamiento del factor de necrosis tumoral alfa e interleucina 6 en lesiones de vías biliares postcolecistectomía. Revista Medica de Chile, 138(10), 1259–1263. https://doi.org/10.4067/s0034-98872010001100008

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