Bohlmann-Rahtz cyclodehydration of aminodienones to pyridines using N-iodosuccinimide

Abstract

Cyclodehydration of Bohlmann-Rahtz aminodienone intermediates using N-iodosuccinimide as a Lewis acid proceeds at low temperature under very mild conditions to give the corresponding 2, 3,6-trisubstituted pyridines in high yield and with total regiocontrol. © 2010 by the authors.