Two breakthroughs in CGD studies

Abstract

Studies in Chronic Granulomatous Disease showed two breakthroughs during this past decade. First, the discovery of 7 Nox/Duox family proteins, Noxo1and Noxa1 (homologues of gp91phox, p47phox and p67phox) may clarify novel physiological mechanisms for superoxide regulation in various organs, such as the regulation of blood pressure, mucosal defense system in respiratory/digestive tract and nephron. Secondly, the success in bone marrow transplantation and gene therapy for CGD should facilitate treatment for other genetic diseases as well. © 2007, The Japan Society for Clinical Immunology. All rights reserved.