Prospective Analysis of Lipid Variations in Hyperthyroid Subjects from Lahore, Pakistan

Abstract

Perturbations in the actions of T3 and T4 influence the normal metabolic pathways. Responsiveness of lipid biomarkers like LDL-C, HDL-C, TC, TG, Apo-A, and Apo-B after rehabilitation of thyroid profile attaining euthyroid state was determined. A total of 179 age-matched subjects of both genders were recruited for this research. Sixty healthy controls, thirty-four subclinical, fifty overt hyperthyroid, and thirty-five follow-up subjects having 3 months of Carbimazole therapy were enrolled. Biochemical analysis was performed by chemistry analyzer, RIA, and ELISA. One-way ANOVA was applied for the statistical analysis, while significance (P<0.05) of means was compared by the Student-Newman-Keuls (SNK) test. Pronounced reduction (P<0.001) of cholesterol in overt as compared to control and subclinical was noticed, whereas marked improvement (P<0.001) was evidenced in follow-up. Prominent elevation (P<0.05) of TG in follow-up was evidenced as compared to control. Overt presented marked reduction of HDL-C as compared to subclinical and control (P<0.01 and P<0.001), respectively. Pronounced elevation (P<0.001) of HDL-C was evidenced after treatment. Overt presented reduction of LDL-C as compared to subclinical and control (P<0.01 and P<0.05, respectively). The follow-up group demonstrated considerable (P<0.001) improvement of LDL-C after treatment and elevation (P<0.05) as compared to control. Overt presented reduction of Apo-B as compared to subclinical and control (P<0.05 and P<0.001, respectively). Improvement (P<0.05) of Apo-B was evidenced in follow-up. Reduction (P<0.05) of Apo-A in overt as compared to control and elevation (P<0.05) in follow-up as compared to overt was evidenced. Conclusively, improvement after treatment was evidenced in lipid profile.