Abstract
D5-labeled isotopomers of atorvastatin, atorvastatin lactone and its hydroxy metabolites were synthesized as internal standards for use in a LC/MS/MS method developed for the simultaneous quantitative determination of atorvastatin and its hydroxy metabolites in human serum. d5-Atorvastatin and d5-atorvastatin lactone were prepared from d5-aniline whereas their corresponding hydroxy metabolites were synthesized using d5-benzaldehyde.
Author supplied keywords
Cite
CITATION STYLE
Chen, B. C., Sundeen, J. E., Guo, P., Bednarz, M. S., Hangeland, J. J., Ahmed, S. Z., & Jemal, M. (2000). Synthesis of deuterium-labeled atorvastatin and its metabolites for use as internal standards in a LC/MS/MS method developed for quantitation of the drug and its metabolites in human serum. Journal of Labelled Compounds and Radiopharmaceuticals, 43(3), 261–270. https://doi.org/10.1002/(SICI)1099-1344(20000315)43:3<261::AID-JLCR312>3.0.CO;2-T
Register to see more suggestions
Mendeley helps you to discover research relevant for your work.
