Synergistic anti-inflammatory and anti-tb effects of Au-Pt-Cu nanofluids: experimental and computational insights

Abstract

Aims: To explore the potent anti-inflammatory and anti-tuberculosis potential of novel trimetallic Au-Pt-Cu nanofluids. Materials & methods: We employed BSA assay for anti-inflammatory assessment and tested anti-tuberculosis activity against Mycobacterium tuberculosis H37Rv. Advanced molecular docking, dynamics, and DFT analyses were conducted to reveal interaction mechanisms and electronic properties. Results: The nanofluids demonstrated impressive IC50 values (15.88 ± 0.09 μM and 0.54 ± 0.02 μg/ml), with strong binding affinities and stable interactions confirmed via molecular simulations. Favorable ADMET profiling highlights their promise as innovative therapeutic agents.