Improvements in Efficiency and Selectivity for C-F Bond Halogen-Exchange Reactions by Using Boron Reagents

Abstract

The use of boron Lewis acids as instigators of bond cleavage offers a number of synthetic possibilities. A unique feature of this class of reagents is the ability to functionalize otherwise inert C F bonds. We summarize notable developments in C F bond halogen exchange using Lewis acidic boron reagents and we conclude by featuring our group s advances in activating CF3 groups by using boron trihalides. 1 Introduction 2 Boron-Mediated Halogen Exchange 3 Mono-Selective C F Activation 4 Conclusions.