MP664PREVALENCE OF FRAILTY AND ITS ASSOCIATION WITH QUALITY OF LIFE, CLINICAL AND BIOCHEMICAL MARKERS IN END-STAGE RENAL DISEASE PATIENTS UNDER DIALYSIS

Abstract

Introduction and Aims: End-stage renal disease patients under dialysis presented an enhanced inflammatory and oxidative stress process, and metabolic disturbances, which contribute to the development of frailty. Being associated with decreased quality of life and increased risk of hospitalization, institutionalization and death. Considering the lack of information about frailty in ESRD patients under dialysis, the aims of this work was to evaluate the prevalence of frailty in these patients, and its association with socio-demographic, clinical and biochemical markers, as well as with quality of life and comorbidities. Method(s): We performed a cross-sectional study with 83 ESRD patients (44 males and 39 females, mean [+/- SD] age: 64.3 [+/-14.6] years) on regular dialysis. The classification of the ESRD patients as robust, pre-frail and frail was performed using the FRAIL questionnaire. Moreover, it was also evaluated the social support and quality of life, as well as data about sociodemographic and comorbidities, and haematological, iron status, dialysis adequacy, nutritional and inflammatory markers. Result(s): We found in our group of ESRD patients a prevalence of pre-frailty and frailty of 54.2% (n=45) and 28.9% (n=24), respectively. When compared the 3 groups of patients (robust, pre-frail and frail), we found a significant increase in proportion of female, diabetes and hypertension in frail group. A significant increase in ferritin level, global deterioration scale score, Beck depression inventory scale score and Charlson comorbidity index score; and a decrease in haemoglobin concentration, iron, transferrin and albumin serum levels, and in mini mental state examination scale score and in physical and mental components summaries of quality of life, were found in frail patients. Moreover, we also found a negative significant correlation between frailty scale score and mini mental state examination scale score, global deterioration scale score, albumin, iron, physical and mental components summary of quality of life and interdialytic weight gain; and a positive significant correlation with depression symptoms and comorbidities. Conclusion(s): In conclusion, our results showed that frailty is a high prevalent condition in ESRD patients under dialysis, particularly in older female patients, which is associated with a decrease in quality of life, cognitive function, nutritional status and with increased depressive symptoms and comorbidities.