The end-product method of measuring whole-body protein turnover: a review of published results and a comparison with those obtained by leucine infusion

  • Duggleby S
  • Waterlow J
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Abstract

The present review summarizes the results of all published papers on whole-body protein turnover in man measured by [ 15 N]glycine and the end-product method using both urea and ammonia. It begins with a short account of the underlying assumptions and the justification for the use of [ 15 N]glycine. The results are then compared with those of a large sample of measurements by the ‘gold standard’ precursor method with continuous infusion of [ 13 C]leucine. The pros and cons of the two methods are compared and it is suggested that there is a place for further work by the less invasive end-product method, particularly for population studies of the genetic, environmental and functional determinants of whole-body rates of protein synthesis.

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Duggleby, S. L., & Waterlow, J. C. (2005). The end-product method of measuring whole-body protein turnover: a review of published results and a comparison with those obtained by leucine infusion. British Journal of Nutrition, 94(2), 141–153. https://doi.org/10.1079/bjn20051460

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