Lithiated carbamates: Chiral carbenoids for iterative homologation of boranes and boronic esters

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Abstract

(Chemical Equation Presented) Take your pick: Either enantiomer of either diastereomer of substrates bearing adjacent stereogenic centers is accessible through reaction of an (R)- or (S)-lithiated carbamate with an (R)- or (S)-boronic ester (see scheme; pin = pinacolate, OCb = substituted carbamate). © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

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Stymiest, J. L., Dutheuil, G., Mahmood, A., & Aggarwal, V. K. (2007). Lithiated carbamates: Chiral carbenoids for iterative homologation of boranes and boronic esters. Angewandte Chemie - International Edition, 46(39), 7491–7494. https://doi.org/10.1002/anie.200702146

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