The MOV10 helicase inhibits LINE-1 mobility

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Abstract

Background: Retrotransposon LINE-1 causes dozens of genetic diseases. Results: Human MOV10 diminishes the level of LINE-1 RNA by acting at a post-transcriptional stage. Conclusion: The host protein suppresses LINE-1 transposition. Significance: MOV10 contributes to the cellular control of LINE-1 replication © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.

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Li, X., Zhang, J., Jia, R., Cheng, V., Xu, X., Qiao, W., … Cen, S. (2013). The MOV10 helicase inhibits LINE-1 mobility. Journal of Biological Chemistry, 288(29), 21148–21160. https://doi.org/10.1074/jbc.M113.465856

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