Targeting nitric oxide for cancer therapy

Abstract

A blueprint for the ideal anticancer molecule would include most of the properties of nitric oxide (NO•), but the ability to exploit these characteristics in a therapeutic setting requires a detailed understanding of the biology and biochemistry of the molecule. These properties include the ability of NO• to affect tumour angiogenesis, metastasis, blood flow and immuno surveillance. Furthermore NO• also has the potential to enhance both radio- and chemotherapy. However, all of these strategies are dependent on achieving appropriate levels of NO•, since endogenous levels of NO• appear to have a clear role in tumour progression. This review aims to summarize the role of NO• in cancer with particular emphasis on how the properties of NO• can be exploited for therapy.