Interaksi Beberapa Senyawa Kalkon Berbasis Parasetamol terhadap Protein Enzim yang Berperan dalam Mekanisme Antibakteri

Abstract

Calcon is a secondary metabolite of the flavonoid group that is found in nature, especially in plants. Calcon has various activities such as cytotoxic, antiviral, anesthetic, antimicrobial, anti-inflammatory, and so forth. The aim of this research is to know the antibacterial activity of calcon-based derived paracetamol compound by using docking method against bacterial protein Escherichia coli and Bacillus subtilis. The results showed that the compound 3- (4-Metoxyphenyl) -N- (4-Chlorophenyl) Acrylamide, 3- (4-Hydroxyphenyl) -N- (4-Chlorophenyl) Acrylamide, and 3- (4-Hydroxy-3-Methoxyphenyl ) -N- (4-Chlorophenyl) Acrylamide showed good activity with an average rmsd-refine score <2. The kalkon derivative binds complex with amino acid bacteria such as Ile 173, Asn 267, Lys A449, Thr 265, and Arg A389.