HUBUNGAN ANTARA KEBIASAAN CARA MEMASAK SAYURAN DAN KADAR CHOLINESTERASE TERHADAP STATUS HORMON THYROID WANITA USIA SUBUR DI DAERAH GONDOK ENDEMIK

Abstract

THE ASSOCIATION BETWEEN FREE THYROXINE AND VEGETABLES COOKING AND SERUM CHOLINESTERASE OF CHILD BEARING AGE WOMEN IN ENDEMIC GOITRE AREA Pesticides, a goitrogenic pollutant, strongly bind iodine to make a complex substance which iodine can not optimally be utilized and leads to impair thyroxine hormone production. Farmers in Pakis sub district of Magelang district often put pesticides of organophosphate and carbamate groups to increase vegetables yield. The retained pesticides in the foods can be minimized by cooking. To determine the association between free thyroxine sera and vegetable cooking and cholinesterase sera. A cross-sectional study design was applied to 205 of child bearing age women (CBAW) of 17 – 45 years of age in Pakis sub district of Magelang District, Central Java. Vegetable in which pesticide may persist were cooked in two ways, namely were boiled and tumis (stir fried). Blood spicement were drawn for fT4 and cholinesterase axamination. It was indicated that serum FT4 of 68,3 % of CBAW were normal, while 31,7 % of them were low and 5.1% of CBAW with low serum CHE. There was a significant association between the way of cooking , status of serum CHE and contraceptive use of family planning with to status of serum FT4. The child bearing age women that consume vegetables cooked by " tumis " (cooking stir fried) having higher risk of low serum free thyroxin status, 2,5 times than that of by boiling. CBAW with low cholinesterase enzyme (CHE) having lower risk of low serum free thyroxin hormone status (FT4), 10 times than that of with normal CHE. CBAW with hormonal contraception having higher risk of low serum FT4, 0,50 times than that usage non hormonal contraception. In order to minimize pesticide residues retained in vegetables, it should be cooked by boiling