Up-regulation of activation markers on basophils in patients with papuloerythroderma

Abstract

Papuloerythroderma is a pruritic eruption of flat-topped papules in a background of erythroderma that characteristically spares skin folds; so-called “deck-chair sign” (1). Histopathology reveals a non-specific spongiotic dermatitis-like pattern, such as slight epidermal hyperplasia with spongiosis and a primarily perivascular dermal infiltrate with lymphocytes, histiocytes and eosinophils. Peripheral eosinophilia and elevated serum immunoglobulin E (IgE) are detected in most cases of papuloerythroderma.