Divergent synthetic approach to 6′′-modified α-GalCer analogues

Abstract

A synthetic approach is presented for the synthesis of galacturonic acid and d-fucosyl modified KRN7000. The approach allows for late-stage functionalisation of both the sugar 6′′-OH and the sphingosine amino groups, which enables convenient synthesis of promising 6′′- modified KRN7000 analogues. © The Royal Society of Chemistry 2011.