Directed Differentation of Human Embryonic Stem Cells in Combination of Biomaterials

Abstract

Human embryonic stem cells (hESC) are derived from the inner cell mass of preimplantation embryos and defined by their extensive self-renewal capacity and their potential to differentiate into any cell types of three germ layers (ectoderm, mesoderm and endoderm). Since the first hESC line was established in the year of 1998, much progress has been made on studies of hESC culture, cell line establishment, and directed differentiation.