Enantioselective β-lactone formation from phenyldiazoacetates via catalytic intramolecular carbon-hydrogen insertion

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Abstract

Dirhodium(II) catalysts with chiral carboxylate or carboxamidate effectively promote β-lactone formation from phenyldiazoacetates in high yield and with up to 63% ee.

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Doyle, M. P., & May, E. J. (2001). Enantioselective β-lactone formation from phenyldiazoacetates via catalytic intramolecular carbon-hydrogen insertion. Synlett, (SPEC. ISS), 967–969. https://doi.org/10.1055/s-2001-14635

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