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Synthesis of 9e- and 9z-locked retinoic acid analogs as ligands for rar and rxr

Chemical and Pharmaceutical Bulletin (1994) 42(12) 2659-2661
DOI: 10.1248/cpb.42.2659
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Abstract

New retinoic acid (RA) analogs 9E-locked-RA 3 and 9Z-locked-RA 4 were synthesized from dithiane 6 and β-cyclocitral 13, respectively. Both analogs behaved as agonistic ligands for a mixture of retinoic acid receptor (RAR) and retinoid X receptor (RXR). © 1994, The Pharmaceutical Society of Japan. All rights reserved.

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Katsuta, Y., Aoyama, Y., Osone, H., Wada, A., Ito, M., Uchiyama, S., … Masushige, S. (1994). Synthesis of 9e- and 9z-locked retinoic acid analogs as ligands for rar and rxr. Chemical and Pharmaceutical Bulletin, 42(12), 2659–2661. https://doi.org/10.1248/cpb.42.2659

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