Application of poly(3,4-ethylenedioxythiophene)/manganese dioxide composite-modified electrode for sensitive electrochemical detection of luteolin

Abstract

In this work, the electrochemical determination of luteolin using poly(3,4-ethylenedioxythiophene)/manganese dioxide nanocomposite modified glassy carbon electrode (PEDOT/MnO2/GCE) is reported. PEDOT/MnO2 nanocomposite has been proposed via a simple two-step deposition approach. Electrochemical results revealed that PEDOT/MnO2 showed enhanced electrocatalytic performance toward luteolin, which might be attributed to good conductivity and accelerated electron transfer of PEDOT and good catalytic effect of MnO2. Experimental conditions, including pH values and scan rates were optimized. In optimal conditions, a good linear relationship was found between oxidation peak currents and the concentration of luteolin in 5.0 nM-7.0 μM range. The detection limit was calculated to be 1.8 nM at a signal-to-noise ratio of 3. Finally, the applicability for luteolin determination in real samples was successfully demonstrated.