0920 Sleep Disturbances In Opioid Dependent Patients On Buprenorphine- Gender Differences In non-compliant Subjects

Abstract

Introduction: Sleep disturbances are common in opioid use disorder (OUD) patients on buprenorphine. The aim of the study is to examine gender differences in the prevalence and factors associated with sleep disturbances in patients with OUDs who are not compliant on buprenorphine. Methods: Follow up data was available for 120/226 subjects recruited from buprenorphine clinics in central PA. 70/120 (58%) were non-compliant/dropped out of treatment within 6 months. Sociodemographic and Pittsburgh Sleep Quality Index (PSQI) collected at baseline were compared between male and females who are non-compliant with buprenorphine treatment using Chi square and t tests. Results: 63% of the male and 80% of the female had PSQI >5 indicating poor sleep quality. Women were more likely to report moderate-to-severe depression (43 %) and anxiety (50%) than men (23%, 37% respectively). Men were older (36±10 years), had longer duration of opioid dependence (126±92 months) and frequent rehabilitation hospitalizations (4±4.5) than women (32±8 years, 75±55 months, and 2±2 respectively, all Ps<0.01). Women had marginally longer adherence to buprenorphine treatment (8.5±10 months) than men (5±6 months, P<0.10). Women had higher scores on PSQI sleep quality (1.8±1), PSQI daytime dysfunction (1.6±1) as compared to men (1.3±0.9, 0.9±0.8, 8.5±5respectively, P<0.05) indicating poor sleep quality and day time dysfunction. Women had marginally higher scores on PSQI total sleep score (11±5) as compared to men (8.5±5, p<0.1). On regression analysis, onset, worsening or no change in sleep problems with buprenorphine treatment predicted poor sleep quality in both groups. Conclusion: Conclusion: Poor sleep quality is highly prevalent in both genders in OUD patients who are non-compliant with buprenorphine. Women are more likely to have severe and frequent sleep disturbance as compared to men. Recognizing and addressing onset of or worsening sleep disturbance with buprenorphine treatment in both genders would help prevent noncompliance and thereby prevent relapse in this patient population.