Three New Chromone Derivatives from the Deep-Sea-Derived Fungus Penicillium thomii

Abstract

Chemical investigation of the EtOAc extract of a deep-sea-derived fungus Penicillium thomii Maire YPGA3 cultured on rice solid medium led to the isolation of three new chromone analogs, named penithochromones U−W (1−3), along with six known compounds (4−9). The structures were determined by extensive analyses of spectroscopic data (NMR and HRESIMS data). Compounds 1−3 are 5,7-dioxygenated chromone analogs bearing an aliphatic acid side chain. All isolated compounds were inactive toward the α-glucosidase at the concentration of 200 μM.