Impacto metabólico e inflamatorio postprandial de una comida rica en grasas saturadas y su relación con la presencia de obesidad abdominal

Abstract

Introduction: The postprandial stage is associated with the increase of markers related to cardiovascular risk, and its intensity depends of the metabolic state. Objective: To determine the impact of high fat meal intake on the metabolic and inflammatory profile and its relation to abdominal obesity. Materials and methods: This clinical trial included 42 individuals (21 with abdominal obesity). We realized measurement of glucose, insulin, lipid profile, reactive C protein, lipopolysaccharides and interleukin 6 in fasting blood, at the hour and 4-hour post-intake. Results: Obesity was accompanied by insulin resistance and higher levels of fasting triacylglycerides and C-reactive protein, and showed higher postprandial responses to glucose, insulin and triacylglycerides. Interleukin 6 decreased in the non-obese group and lipopolysaccharides increased in both groups. Conclusions: A saturated high-fat food intake produces a greater impact on the glycemic variables in the group with obesity. It similarly affects the lipids in both groups, but the increase of triacylglycerides is higher in the presence of elevated basal concentration and promotes the increase of lipopolysaccharides. The basal and postprandial inflammatory state most affects the group with obesity. The postprandial moment reflects the most frequent state of the individuals on a normal day and allows showing the capacity of metabolic response to the food intake as well as to demonstrate early metabolic risk.