On-Line determination of serum propofol concentrations by expired air analysis

Abstract

Propofol (2,6-diisopropylphenol)-an intravenous anaesthetic-can be identified and quantified in expired air directly. For the first time, a β-radiation ion mobility spectrometer operated in the positive mode and coupled to a multi-capillary column for rapid (seconds-minutes) pre-separation (MCC/IMS) was used for the quantification of Propofol in expired air. The comparison of the concentrations in exhaled air (300 pptV-5 ppbV) and in serum (0. 3-5 μg/mL) showed satisfying agreement affirmed by a correlation coefficient of 0. 73. Therefore, MCC/IMS is an adequate method to determine Propofol concentrations in exhaled air and may be applied for the prediction of venous concentrations or for automatic anaesthesia control. © 2010 Springer-Verlag.