Effect of high-dose selenium substitution on selected laboratory parameters and prognosis in critically ill patients

Abstract

High doses of selenium (Se) may improve the condition of ICU patients with respect to its involvement in antioxidative protection and other tasks. One hundred and forty patients were randomized into groups A and B. Group A received standard Se substitution: 30 to 75 g/day NaSelenite intravenously; group B received Se substitution according to a protocol: 1,000 g at day 1, followed with 500 g at days 2 to 14.