For decades, the main question immunologists have asked about autoimmunity is “what causes a break in self-tolerance?” We have not found good answers to that question, and I believe we are still so ignorant because it’s the wrong question. Rather than a break in self-tolerance, I suggest that many autoimmune diseases might be due to defects in normal tissue physiology.
CITATION STYLE
Matzinger, P. (2022). Autoimmunity: Are we asking the right question? Frontiers in Immunology, 13. https://doi.org/10.3389/fimmu.2022.864633
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