Mice deficient in γδ T cells are resistant to lethal infection with Salmonella choleraesuis

Abstract

Mice deficient in γδ T cells were resistant to the gram-negative bacteremic sepsis caused by infection with a high dose of Salmonella choleraesuis accompanied by impaired tumor necrosis factor alpha production in vivo and in vitro. γδ T cells may play a role in the pathogenesis of lethal infection with S. choleraesuis.