Synthesis and Antihyperlipidemic Activity of Piperic Acid Derivatives

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Abstract

A series of piperic acid derivatives were designed and synthesized from piperine/ piperlonguminine, and their antihyperlipidemic activities evaluated in dietinduced hyperlipidemic rats with respect to simvastatin. Two promising analogues 3 and 10 were discovered and their antihyperlipidemic activities were comparable to or better than those of simvastatin.

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Rong, A., Bao, N., Sun, Z., Borjihan, G., Qiao, Y., & Jin, Z. (2015). Synthesis and Antihyperlipidemic Activity of Piperic Acid Derivatives. Natural Product Communications, 10(2), 289–290. https://doi.org/10.1177/1934578x1501000218

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