A Case of Malignant Pheochromocytoma Treated with 131I-Metaiodobenzylguanidine and CVD Regimen

Abstract

A 44-year-old male had multiple metastasis to the lung, liver, kidney and paraaortic lymphnode from primary adrenal malignant pheochromocytoma. Radiation therapy with 131I-metaiodobenzylguanidine (131I-MIBG), was first performed, which was followed by chemotherapy with cyclophospamide, vincristine and dacarbazine (CVD). A total amount of 4810 MBq of 131I-MIBG was administered then 7 cycles of CVD regimen were added. He was survived for sixteen months with tumor response in primary tumor, paraaortic lymphnode and liver metastasis tumors, in addition to hormonal response. It was considered that the survival was prolonged in spite of advanced case with inoperative primary tumor. © 1994, THE JAPANESE UROLOGICAL ASSOCIATION. All rights reserved.