Wearable Devices for Multimodal Optical Diagnostics of Microcirculatory-Tissue Systems: Application Experience in the Clinic and Space

Abstract

This work demonstrates some results of the successful experience of using wearable devices for multimodal optical diagnostics of microcirculatory-tissue systems both in clinical practice and in the conditions of a Space experiment. The multimodal approach based on simultaneously applying a minimum of 2 optical diagnostic methods, for example, laser Doppler flowmetry and fluorescence spectroscopy, allows analysing of blood flow and metabolic processes in biological tissue more systematically. Combining several wearable devices into a distributed diagnostic system allows placing them simultaneously on symmetrical parts of the body (such as opposite limbs) thus providing a possibility to study the symmetry of the measured signals. The obtained data on the state of the microcirculatory-tissue systems of the human body recorded with wearable multimodal devices make it possible to assess the relationship and dynamics of oxygen delivery and utilization by tissues more comprehensively and reliably in a variety of diagnostic tasks.