Induction of Lymphoma in CDF1 Mice by the Food Mutagen, 2‐Amino‐l‐methyl‐6‐phenylimidazo[4,5‐b]pyridine

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Abstract

The mutagenic compound, 2‐amino‐l‐methyl‐6‐phenylimidazo[4,5‐b]pyridine (PhIP), originally isolated from cooked beef, was tested for carcinogenicity in CDF1 mice of both sexes. When PhIP was given in the diet at a concentration of 0.04%, high incidences and early appearances of lymphomas were observed in both sexes during the 579‐day experiment. Copyright © 1989, Wiley Blackwell. All rights reserved

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Esumi, H., Ohgaki, H., Kohzen, E., Takayama, S., & Sugimura, T. (1989). Induction of Lymphoma in CDF1 Mice by the Food Mutagen, 2‐Amino‐l‐methyl‐6‐phenylimidazo[4,5‐b]pyridine. Japanese Journal of Cancer Research, 80(12), 1176–1178. https://doi.org/10.1111/j.1349-7006.1989.tb01651.x

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