Markers of vascular wall fibrosis metalloproteinase-9 and tissue inhibitor of metalloproteinases-1 in patients with ischemic heart disease with and without concomitant type-2 diabetes mellitus

Abstract

The prevalence of ischemic heart disease (IHD) and diabetes mellitus type 2 (DM type 2) is permanently increasing both world- wide and in the Russian Federation. That is why studies of mechanisms of pathogenesis of both diseases is continuing for preven- tion of complications and mortality. DM type 2 contributes a lot to deterioration of IHD. One of pathogenetic features these two pathologies share is pronounced blood vessel wall fibrosis. In this review we present analysis of studies devoted to the determination of the role of metalloproteinase-9 and tissue inhibitor of metalloproteinases-1 in development of vascular wall fibrosis.