Endoplasmic reticulum and Golgi apparatus: Old friends, novel intimate relationships

Abstract

The nature of the physical contacts between the endoplasmic reticulum and the Golgi apparatus has been debated for many years. Using advanced optical tweezer technology in living cells, Osterrieder et al. (2017) have now identifed a Golgi membrane tethering protein that participates in anchoring Golgi stacks to the endoplasmic reticulum, opening the way to further functional studies of the role of these intimate relationships.