Hypoxaemia and release of endothelin-1

Abstract

Background - Secretion of the vasoconstrictor peptide endothelin-l from vascular endothelium is increased by various stimuli. Whether hypoxaemia affects plasma levels of endothelin-1 in humans is unknown, but this may be important in the haemodynamic response to hypoxaemia. The plasma endothelin-l concentrations in hypoxaemic humans has therefore been measured. Methods - Plasma levels of endothelin-I were measured by specific radioimmunoassay in 10 control subjects at rest and following 30 minutes of acute hypoxaemia (Sao2 75-80%) induced by breathing a nitrogenloxygen mixture, and in 10 patients with hypoxaemic cor pulmonale. Results - The plasma endothelin-I concentration in control subjects was increased from a mean (SE) of 0 90 (0.11) pmolll at baseline to 2'34 (0.34) pmoMl during hypoxaemia. In patients with cor pulmonale the plasma endothelin-I concentration was 2'96 (0.34) pmol/l, raised in comparison with control subjects at rest but similar to levels in controls during hypoxaemia. Conclusions - Plasma levels ofendothelin-1 were increased by hypoxaemia in humans. The raised levels observed in patients with cor pulmonale maylargely be attributable to the effects of hypoxaemia, although the pathophysiological significance of these observations remains to be established.