Passerini multicomponent reaction of indane-1,2,3-trione: An efficient route for the one-pot synthesis of sterically congested 2,2-disubstituted indane-1,3-dione derivatives

Abstract

The Passerini reaction of indane-1,2,3-trione, isocyanides and benzoic acid derivatives proceed at room temperature and sterically congested 2,2-disubstituted indane-1,3-dione derivatives are synthesized in excellent yields. The reaction proceeds smoothly and cleanly under mild conditions and no side reactions are observed. ©2009 Sociedade Brasileira de Química.