Amino Acids and Peptides. VIII.1)A Water-Soluble Active Ester, Phenolsulfonic Acid Derivative

Abstract

N-Protected amino acid 4-phenolsulfonic acid derivative esters, such as 2,6-dibromo-4-sulfophenyl ester sodium salt, 2,6-dichloro-4-sulfophenyl ester potassium salt and 2-nitro-4-sulfophenyl ester sodium salt, were prepared. These esters are water-soluble active esters, and were applied for the synthesis of Leu-enkephalin. © 1987, The Pharmaceutical Society of Japan. All rights reserved.