Effect of Addition of Ethanol Extract from Sijukkot Leaves (Lactuca Indica L.) on Cholesterol Reduction in Male Strain Rats (Rattus Norvegicus)

Abstract

Cholesterol is one of the lipids that can form cell membranes and extremity layers and functions as a lipoprotein compound. Rising cholesterol levels can cause various diseases. The leaves of the sijukkot plant have been used as a lowering of cholesterol levels in the body. By using SPSS analysis, it was found that the Shapiro-Wilk Normality Test with a sig value > 0.05, the data were normally distributed. The results of the analysis in the Test of Homogeneity of Variances table obtained a Sig value of 0.510. Thus the value of Sig = 0.510 > 0.05, then Ho is accepted. Thus, the ethanol extract of sijukkot leaves has the potential to reduce cholesterol levels. By using four different doses, the rat group at a dose of 100 mg/kgBW showed cholesterol levels of 77.25 (mg/dL) ± 9.14, the rat group at a dose of 200 mg/kgBW showed cholesterol levels of 62.75 (mg/dL) ± 5.44, the rat group at a dose of 200 mg/kgBW showed a cholesterol level of 62.75 (mg/dL) ± 5.44. 300 mg/kgbw showed a cholesterol level of 61.50 (mg/dL) ± 4.1 and a group of rats at a dose of 400 mg/kgbw showed a cholesterol level of 54.50 (mg/dL) ± 4.1