Iridium-catalyzed arylative cyclization of alkynones by 1,4-iridium migration

Abstract

1,4-Metal migrations enable the remote functionalization of C-H bonds, and have been utilized in a wide variety of valuable synthetic methods. The vast majority of existing examples involve the 1,4-migration of palladium or rhodium. Herein, the stereoselective synthesis of complex polycycles by the iridium-catalyzed arylative cyclization of alkynones with arylboronic acids is described. To our knowledge, these reactions involve the first reported examples of 1,4-iridium migration. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.