An Updated Review of Novel Nanogels as Versatile Nano-Platforms for Biomedical and Pharmaceutical Applications

Abstract

Nanogels have been materialized in recent years as a suitable vehicle for the transport and delivery of drug cargo to patients and have been developed as a part of nanomedicines. Nanotechnology drug delivery system has been emerged to fashion their defined field in this interface. By description, nanogels are 3D sub-micron sized cross-linked polymer systems. Nanogels are made of hydrogel particulate constituents with a size range of nanometers; hence, it possesses both hydrogels and nanoparticles properties. Nanogels have some exceptional properties making them an idea delivery system in various fields including diagnosis, chemotherapeutics, and delivery of genes and targeting specific organs. These ideal properties are stability, better permeation and drug loading ability, responsiveness to environmental stimuli and biologic consistency. This review emphasis chiefly on various types of nanogels, preparation strategies as well as drug loading methods, degradation mechanisms, and drug release mechanisms of drug from nanogels. In this article, we look at these innovative drug delivery systems in more detail with latest pharmaceutical and biological applications of nanogels.